10 Cannabinoids You Didn’t Know About

10 Cannabinoids You Didn’t Know About

by | Feb 5, 2018

10 Cannabinoids You Didn’t Know About

Cannabinoids, CBD, Hemp Oil and now 10 more Cannabinoids? Yep, we’ve all heard of the two main terms related to our favorite herb – THC and CBD.  Acting as the two main “ingredients” in marijuana, they’re scientifically called cannabinoids.  But, little do most know, there are DOZENS, if not hundreds, of different cannabinoids in the cannabis plant. Today, we’re going to look at 10.

THC

Often known as marijuana’s “flagship” cannabinoid, THC is the poster boy of weed, and is scientifically named Delta(9)-Tetrahydrocannabinol.

As one of the “main” active ingredients in weed, this is what turns you from sober to stoned!.

Not only does it get you high, but it has medicinal values to it as well!s.

It can treat:

  • Crohn’s disease
  • Neuropathy
  • PTSD
  • Cancer
  • Alzheimer’s
  • Multiple Sclerosis
  • Parkinson’s
  • Arthritis
  • Asthma
  • Glaucoma
  • AIDS/HIV

THC is obviously quite diverse in its abilities to treat diseases, and is held in high esteem among cannabis lovers.

CBD

As you can expect, after THC, there is CBD.

Known as Cannabidiol, this is the cannabinoid most associated with medicinal properties.

With its great healing capabilities, here are some of the illnesses or issues that it can help alleviate:

  • Pain relief and inflammation
  • Epilepsy
  • Multiple Sclerosis
  • Anticancer
  • Schizophrenia
  • Anti-tumor
  • Anti-anxiety

There are even more benefits to CBD than what’s listed.

This video below will tell you everything you need to know about CBD.

CBC

Unbeknownst to most, there are more than two ingredients inside of marijuana.

One of the more recent discoveries is a cannabinoid called Cannabichromene – CBC for short.

Although the average pot smoker is ignorant to the fact that this exists, CBC is the third most common cannabinoid in weed, and can even rival the amount of CBD content in certain strains!

CBC does NOT get you “high”…

The receptors that it binds to are linked to pain perception – the Vanilloid Receptor 1 (TRPV) and the Transient Receptor Ankyring 1 (TRPA1).

CBC has some of its own unique medical properties.

They include:

  • Anti-fungal
  • Anti-bacterial
  • Antidepressant
  • Encourages new brain cell growth (neurogenesis)
  • Anti-inflammatory

There was a study done that says it even helps digestive issues associated with diarrhea and constipation.

While these benefits can be found within the cannabinoid CBC, they work even better in tandem with THC.

This effect is known as the entourage effect.

Essentially, isolating CBC and creating a product of just pure CBC would NOT be as effective without its other cannabinoid friends..

CBN

CBN, or Cannabinol, can be found as a metabolite of THC.

Due to the oxidation of the plant’s chemicals, this means that it’s a byproduct of THC through the aging process..

Among having similar benefits that the other cannabinoids have, its most notable characteristic is that it promotes bone growth.

In most cannabis plants, THC can go up to around 30%.

In comparison, CBN RARELY exceeds 1%!

As for a more mainstream application of this cannabinoid, it would be best suited for its sleep aid properties.

When you’re feeling tired from smoking cannabis, it’s likely due to cannabinol.

CBG

CBG, or Cannabigerol, is known to treat digestive issues, glaucoma, cancer, skin conditions, and acts as both an antiseptic and a neuroprotective.

As a precursor to THC, CBG converts into THC as marijuana matures over time.

Because of this, there is often a lower amount in most strains. CBG can usually be found in amounts up to 1% of the plant!

But without CBG, we wouldn’t have the weed we know and love today. It is the “mother cannabinoid” and we have it to thank for producing our desired THC and CBD molecules.

However, CBG has properties that can be utilized for medical purposes so growers and researchers are working on finding ways to increase the amount found in plants.

Since it’s a precursor, some breeders are experimenting with selective genetics and extraction of CBG in the earlier stages of cannabis growth.

THCv

If you can pronounce this properly on your first try, you deserve an award.

Tetrahydrocannabivarin is a chemical structure that is very similar to that of THC, and will help potentiate the effects of it.

Similar to THC, THCv has some great benefits attached to it.

THCv is an anticonvulsant, neuroprotective, and more uniquely, it can even promote weight loss!

In this study, it shows that THCv has potential for reducing body fat and increasing energy levels.

Additionally, a study by GW pharmaceuticals showed promising evidence for THCv treating Type 2 diabetes.

It seems like the cannabis plant is just a gift that keeps on giving!

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CBDv

CBDv, or Cannabidivarin, is to CBD what THCv is to THC.

Mostly found in indicas, this cannabinoid has powerful anti-convulsant properties and is shown to suppress the expression of genes associated with epilepsy!

GW pharmaceuticals actually began a Phase II for clinical studies of cannabidivarin in epilepsy in 2015.

They’re planning for CBDv to become “the next generation of standard epilepsy medication”.

Although it is a very confident statement, the future is looking bright for cannabinoids becoming legitimate medicines for a huge list of diseases and disorders.

Delta(8) – THC

Delta-9-Tetrahydrocannabinol is what we refer to as THC normally but, did you know there is a Delta-8-Tetrahydrocannabinol as well?!

Although it is quite similar to Delta-9-THC, its potency is nowhere near as strong.

They do, however, have similar effects which include:

  • Antiemetic,
  • Appetite-stimulating
  • Anti-nausea
  • Anticancer
  • Antitumoral

The U.S. National Cancer Institute conducted research to confirm the benefits Delta-8-THC.

Even though these were studies conducted by the NCI, which is funded by the government, we’ve still seen these chemicals demonized by the same government and not approved by the FDA…

THCa

The last two cannabinoids (that you didn’t know about) are to be found in the plant substance before they’re decarboxylated.

This means that you don’t receive their unique benefits if you heat them up.

But what exactly are these benefits?

  • Anti-inflammatory
  • Antioxidant
  • Improves gastrointestinal functions
  • Neuroprotective
  • Antiemetic
  • Insecticide

The insecticide capabilities in THCa may prove to be useful by adding raw cannabis oil to lotions and creams for topical use.

These benefits present a good reason as to why individuals may consider consuming raw cannabis!

Some might even say… superfood!

CBDa

cannabinoids - cbda

As with THCa, CBDa’s benefits can only be redeemed if you eat them raw.

  • Anti-inflammatory
  • Antioxidant
  • Painkiller
  • Anti-proliferative

Anti-proliferative help slow the spread of malignant cells in the body.

So combined with the other anti-cancer properties of the other cannabinoids we’ve mentioned, the cannabis plant in raw form could be a powerful cancer-fighting substance.

Conclusion about Cannabinoids:

Marijuana plays hosts to plenty of “ingredients” that can help with several different medical issues.

Researchers and growers are working desperately to extract certain cannabinoids to help with specific problems, which will eventually become a huge help in the medical field.

But for now, all we can do is wait until medical marijuana is a widespread and mainstream prescription!

Which cannabinoid seems like it would be most beneficial to you? Let us know in the comments below!

We are grateful for all contributions who help others discover the HEMP/CANNABIS WORLD, via HempingtonPost.com

This Blog was graciously provided to HempingtonPost

HEMP for our Four-Legged Family!

HEMP for our Four-Legged Family!

by | Feb 5, 2018

If you’re wondering, is Hemp safe for my animals and what are the health benefits of hemp for my four-legged family? Consider what you can give your precious animals to help them cope with the stress of life?  Poor eating habits and little exercise will cause health challenges; Please consider hemp products over pharmaceuticals!

The Health Benefits of Hemp in pets Hemp protein powder and hemp seed oil are not only super-foods for people but can also do wonders for your pet (including dogs, cats).  Our animals have endocannabinoid systems with receptors for cannabinoids throughout their body just like humans – CBD is food and creates balance in their system just like humans – CBD cannot be harmful to anyone and it does take time to find the best CBD for your system.  Begin with smaller doses and adjust as you go along.

Benefits include: ○ strengthens the immune system ○ supports a healthy weight ○ increases energy ○ improves the condition of skin and fur unlike many other foods, hemp is easily digestible by the body and shown to aid the system in any recovery work it needs to do, as well as for the maintenance of good health. While the movement towards incorporating hemp into a companion animal’s diet is still in its infancy, veterinarians are also slowly starting to discover the value of this miracle plant.

Hemp Seed Meal and Hemp Oil Hemp seed is known globally for its use in food because it is high in Essential Fatty Acids – the omegas, omega-3, omega-6, omega-9 and GLA, as well as being high in protein that contains all the amino acids. Legislation from country to country varies and you need to check with your countries legislation before following any tips you may hear. Hemp seed meal is the product that remains after the seed has been crushed and the oil extracted. Hemp seed meal still contains 25% protein and provides an excellent dietary source of fiber for humans and animals. 

read more https://www.hempfoods.com.au/assets/uploads/2014/04/Hemp-Dogs.pdf

How And Why Our Brain Makes Its Own Cannabinoids

How And Why Our Brain Makes Its Own Cannabinoids

by | Dec 14, 2017

HOW AND WHY OUR BRAIN MAKES ITS OWN CANNABINOIDS

The Endocannabinoid System (ECS) -by Anne Marie, HempEdification

As you probably already know, unlike water, alcohol and many top-selling pharmaceuticals, it’s impossible to overdose on Cannabis. What you might not realize, however, is that this remarkable attribute of Cannabis stems in part from the fact the human body actually produces its own ‘endogenous’ (made in the body) cannabinoids (endocannabinoids).

Cannabinoids, whether formed in the brain or inhaled via a vaporiser for example, fit neatly into a series of specialised receptors located throughout the body, with their greatest concentration in: the hippocampus (regulates memory); the cerebral cortex (cognition); the cerebellum (motor coordination); the basal ganglia (movement); the hypothalamus (appetite); and, the amygdala (emotions). Cannabinoid receptors are similarly found in “every animal species down to the sponge”, said Dr Donald Abrams, Professor of Clinical Medicine at the University of California San Francisco, Chief of Hematology / Oncology at San Francisco General Hospital and a leading medical Cannabis researcher.

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Dr Abrams was speaking about cannabinoid receptors and the potential therapeutic benefits of THC in children with serious illnesses. When compared to the side effects of other drugs commonly prescribed to kids with cancer, the decision of parents to administer highly-concentrated Cannabis oil to their sick children seems to be a better choice.

First identified in the late 1980’s, the Endocannabinoid System (ECS) consists of cannabinoid (CB1) receptors predominantly located in the nervous system, connective tissues, gonads, glands and organs; and cannabinoid (CB2) receptors, primarily found in the immune system and the spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands and reproductive organs. These receptors can be stimulated and modulated by compounds called endocannabinoids that are produced naturally in the body, like anandamide (ananda is the Sanskrit word for bliss); by ingesting a set of closely-related botanically-based phytocannabinoids like tetrahydrocannabinol (THC), Cannabis’ best known and most psychoactive compound; or by ingesting synthetic cannabinoids produced in a laboratory. After binding to receptors in the body that fit them like a lock fits a key, these endo, phyto and synthetic cannabinoids all produce a wide range of physiological effects, altering everything from blood pressure to pain response to memory to appetite to consciousness.

cannabinoidtimeline

“The endogenous cannabinoid system, named after the plant that led to its discovery, is perhaps the most important physiologic system involved in establishing and maintaining human health”, Dr Dustin Sulak, a leading practitioner of what some have dubbed ‘cannabinopathic medicine’, said during a lecture at the 2010 NORML convention. “In each tissue, the cannabinoid system performs different tasks. But the goal is always the same: homeostasis, the maintenance of a stable internal environment despite fluctuations in the external environment”. Think of the ECS as your body’s ‘root level’ operating system, a kind of central processing unit that regulates and alters the functioning of many other important systems and keeps them in balance.

Cannabinoids2

Martin Lee, author of, ‘Smoke Signals: A Social History of Marijuana’, notes cannabinoid receptors are more abundant in the brain than any other type of neurotransmitter receptor and “function as subtle sensing devices, tiny vibrating scanners perpetually primed to pick up biochemical cues that flow through fluids surrounding each cell … When tickled by THC or its endogenous cousins, these receptors trigger a cascade of biochemical changes on a cellular level that puts the brakes on excessive physiological activity. Endocannabinoids are the only neurotransmitters that engage in such ‘retrograde signaling’ a form of intracellular communication that inhibits immune response, reduces inflammation, relaxes musculature, lowers blood pressure, dilates bronchial passages and normalizes overstimulated nerves. Retrograde signaling serves as an inhibitory feedback mechanism that tells other neurotransmitters to ‘cool it’ when they are firing too fast”.

In a 2006 study published in Pharmacological Review, National Institute of Health researcher Pal Pacher, M.D., Ph.D explained the cognitive leap that took place.

“In the past decade, the Endocannabinoid System (ECS) has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs. Modulating the activity of the Endocannabinoid System (ECS) turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson’s and Huntington’s disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome and osteoporosis, to name just a few”.

rimonabant1But what happens when you purposefully disrupt the body’s ability to stimulate the ECS? Things can go haywire, as discovered when ‘Big Pharma’ tested Rimonabant, an anti-obesity drug designed to create a kind of ‘reverse munchies’ by preventing cannabinoids (endo or phyto) from binding to CB1 and CB2 receptors. Those enrolled in a planned 33-month study of Rimonabant did report lower overall appetite when taking the drug, but they also demonstrated an increased risk of suicide so pronounced that the study was abandoned after little more than a year and four suicides! “Patients taking Rimonabant reported feeling severely depressed and having serious thoughts about committing suicide”, Psychology Today reported. “It was as though the patients had lost their ability to experience pleasure… [Which] tells neuroscientists that our endogenous marijuana* system is normally involved, either directly or indirectly, in controlling our mood and allowing us to experience pleasure; antagonizing the actions of this chemical in the brain leads to depression with possibly dangerous consequences”.

Researching the Truth about Cannabis and Hemp
And yes, here’s hoping for a very hempy celebration season – AnnMaria HempEdification http://hempedification.blogspot.com/

CBD and Our Endocrine System

CBD and Our Endocrine System

by | Nov 2, 2017

Lately, many people have shared with me how completely exhausted they are for no reason.  Many have shared that their doctors say. their endocrine system is out of balance, not working properly and even shut down.  This is very concerning since I know our endocannabinoid system and our endocrine system are directly connected.

The challenge has been, over the past 80 years, not many people have been ingesting cannabis to feed their endocannabinoid system which balances the homeostasis of the endocrine system.  I’m no expert in this field, however, I have learned so much about our internal systems over the past few years in the hemp world that’s I’m excited to continue sharing this information with you.

Because we have experts in this area, I am turning to Linda & Tyler Struse to give us even greater detail on this life-enhancing and life-saving discovery!  take it all in – Darlene Mea, Producer, HempingtonPost

The Role of the Endocannabinoid System in Restoring the Endocrine System.

written by Tyler Strouse of RandysClub.org

Over the last few years, cannabis and the endocannabinoid system have emerged as a topic of interest among patients and those within the scientific community.

The endogenous cannabinoid system (ECS), named after the cannabis plant that led to its discovery, is one of the most important physiological system involved in establishing and maintaining human health. Endocannabinoids and their receptors, CB1 and CB2,  are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. In each tissue, the ECS performs different tasks with the goal of maintaining homeostasis, the maintenance of a stable internal environment despite fluctuations in the external environment.

The endocrine system is the collection of glands in the body that secrete hormones into the bloodstream to be carried towards distant target organs. The central neuroendocrine systems is the interface between the brain and the rest of the endocrine systems. The part of the brain that balances the release of hormones in the body is called the hypothalamus and sits right on top of the pituitary gland where it regulates stress, metabolism, growth, reproduction, and lactation.

All of these processes are regulated by the hypothalamus releasing or inhibiting the release of hormones by the pituitary gland. The release of pituitary hormones affects downstream physiological functions. Other hypothalamic neuroendocrine cells control water/salt balance, and lactation and childbirth, through the release of vasopressin and oxytocin. Together, these hypothalamic neuroendocrine functions enable the central nervous system to respond rapidly to internal or external environmental change, and to maintain a response through endocrine hormonal transducers. The ECS modulates the regulation of the neuroendocrine system, which regulates organ function and stress response and helps maintain a healthy balance across the neuroendocrine system and related physiological body system.

Targeting the Endocannabinoid System for Endocrine Regulation

Cannabinoids in cannabis have long been known to be able to affect the secretion of pituitary hormones. By way of the ECS we regulate our hormonal balance, both up and down, through a direct effect on the organs themselves. The stimulation of the hypothalamic-pituitary-adrenal (HPA) axis is a crucial neuroendocrine response to stress and is dependant on CB1 receptor-mediated signaling. Activating the CB1 receptors in the hypothalamus results in a signaling cascade that ultimately inhibits overall neuroendocrine function. Stress is well known to affect endocrine function and a poorly regulated endocrine system can lead to major health problems. The endocrine response, as part of the HPA axis, is central to its regulation.

Up until a few years ago, the stimulatory effects of cannabinoids on the HPA axis was considered as an exception. The commonly accepted view of the ECS was that it played a general inhibitory role on neuroendocrine functions. We now understand that cannabinoids can have both stimulatory and inhibitory effects on the HPA axis which is how it’s able to modulate its regulation. These biphasic effects of cannabinoids, both stimulatory and inhibitory, are increasingly revealing themselves as we look closer at the interactions between the ECS and the endocrine system.

Cannabidiol (CBD)

This brings us to the cannabinoid du jour, cannabidiol or CBD. Long playing the second fiddle to the more active tetrahydrocannabinol (THC), CBD does not interact strongly with either the CB1 or CB2 receptors. Instead, CBD is able to increase endocannabinoid tone by inhibiting fatty acid amide hydrolase (FAAH) and enzyme that breaks down cannabinoids in the body.  FAAH inhibitors may be helpful for people with anxiety-related disorders because they appear to improve the regulation of the HPA axis. It’s unknown precisely how this happens, but it appears they help to modulate the sensitivity of the cannabinoid receptors in the body.

In addition to its stimulatory effects on HPA, the ECS also plays a critical inhibitory role in regulating HPA functions. Researchers found that endocannabinoid signaling negatively modulates the stress-induced activation of the HPA axis, confirming the notion that an increase in endocannabinoid signaling activity may constitute a novel approach to improving the lives of people with anxiety-related disorders.

Currently, the best way to boost endocannabinoid signaling, improve the regulation of the HPA,, and promote a healthy endocrine system is the use of a dietary cannabinoid supplement made from hemp. These products contain naturally occurring cannabinoids, including CBD, which has been shown to naturally increase ECS tone which helps to improve the regulation of homeostasis across the HPA axis. This will improve both the physiological and psychological responses to stress making us more likely to resist the cascade that leads to HPA dysfunction and endocrine-related health problems. Enjoy a cannabinoid supplement every day!

Source: Uberto Pagotto, Giovanni Marsicano, Daniela Cota, Beat Lutz, Renato Pasquali; The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance, Endocrine Reviews, Volume 27, Issue 1, 1 February 2006, Pages 73–100, https://doi.org/10.1210/er.2005-0009

‘I, Darlene Mea, producer of HempingtonPost.com have discovered over the past few years ‘we have an endocannabinoid system’ AND CBD is the absolute best food ever for our entire body’.  I use CBD daily, it has changed my vitally level immensely’.

The following article is written specifically for HempingtonPost.com from our most trusted source, www.RandysClub.org – We appreciate this company because their dedication is beyond the frenzy of the dollar – it is their mission to help heal the world with cannabis hemp products.

 

Industrial Hemp: Superhero/Savior of Humanity

Industrial Hemp: Superhero/Savior of Humanity

by | Aug 23, 2017

The Book “Industrial Hemp” brings together some of the leaders of the industrial hemp movement to discuss their views, research, and experience.

The articles range from poetry by Native American activist John Trudell to an interview with David Bronner and Will Allen as they reminisce over being arrested for protesting in front of the DEA offices against the fact that industrial hemp is still considered to be a Schedule I substance. Established contemporary artists Karen Gunderson and Glenn Goldberg create work from and about hemp while Mitch Epstein, one of the finest photographers of his generation, takes a stunning cover portrait of Alex White Plume wearing his grandfather’s feather bonnet.

Mia Feroleto, the producer and creative director of HEMP NY CITY, edits this collection to share what is and the possibilities of what can be with industrial hemp.

1. Eric Steenstra, Executive Director of Vote Hemp on the history of industrial hemp and the industrial hemp movement

2. Joel Stanley, CW Botanicals on the creation of Charlotte’s Web.

3. Michael Carus, Nova board member of the EU Industrial Hemp Association on hemp in the EU.

4. Jeffrey Silberman, Chairman of the Sustainable Textiles Department at FIT on hemp textiles.

5. Will Allen, farmer and activist, named one of the 50 most influential people by Politico; and David Bronner of Dr. Bronner’s Magic Soap on their experience in the hemp movement as activists.

6. Glenn Goldberg, artist on his experience at Dieu Donne making handmade hemp paper works.

7. Mike Lewis, founder of Growing Warriors and hemp farmer in Kentucky on farming hemp and the founding of Growing Warriors.

8. Heather Jackson, Executive Director of The Realm of Caring Foundation, on her personal experience.

9. Steve Allin, builder, on building with hempcrete around the world.

10. Michael Reif, attorney, and Marcus Grignon, farmer, and activist, on Native American issues with farming hemp.

You can view this outstanding publication here.