HOW AND WHY YOUR BRAIN MAKES ITS OWN CANNABINOIDS
The Endocannabinoid System (ECS) -by Anne Marie, HempEdification
As you probably already know, unlike water, alcohol and many top-selling pharmaceuticals, it’s impossible to overdose on Cannabis. What you might not realize, however, is that this remarkable attribute of Cannabis stems in part from the fact the human body actually produces its own ‘endogenous’ (made in the body) cannabinoids (endocannabinoids).
Cannabinoids, whether formed in the brain or inhaled via a vaporiser for example, fit neatly into a series of specialised receptors located throughout the body, with their greatest concentration in: the hippocampus (regulates memory); the cerebral cortex (cognition); the cerebellum (motor coordination); the basal ganglia (movement); the hypothalamus (appetite); and, the amygdala (emotions). Cannabinoid receptors are similarly found in “every animal species down to the sponge”, said Dr Donald Abrams, Professor of Clinical Medicine at the University of California San Francisco, Chief of Hematology / Oncology at San Francisco General Hospital and a leading medical Cannabis researcher.
Dr Abrams was speaking about cannabinoid receptors and the potential therapeutic benefits of THC in children with serious illnesses. When compared to the side effects of other drugs commonly prescribed to kids with cancer, the decision of parents to administer highly-concentrated Cannabis oil to their sick children seems to be a better choice.
First identified in the late 1980’s, the Endocannabinoid System (ECS) consists of cannabinoid (CB1) receptors predominantly located in the nervous system, connective tissues, gonads, glands and organs; and cannabinoid (CB2) receptors, primarily found in the immune system and the spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands and reproductive organs. These receptors can be stimulated and modulated by compounds called endocannabinoids that are produced naturally in the body, like anandamide (ananda is the Sanskrit word for bliss); by ingesting a set of closely-related botanically-based phytocannabinoids like tetrahydrocannabinol (THC), Cannabis’ best known and most psychoactive compound; or by ingesting synthetic cannabinoids produced in a laboratory. After binding to receptors in the body that fit them like a lock fits a key, these endo, phyto and synthetic cannabinoids all produce a wide range of physiological effects, altering everything from blood pressure to pain response to memory to appetite to consciousness.
“The endogenous cannabinoid system, named after the plant that led to its discovery, is perhaps the most important physiologic system involved in establishing and maintaining human health”, Dr Dustin Sulak, a leading practitioner of what some have dubbed ‘cannabinopathic medicine’, said during a lecture at the 2010 NORML convention. “In each tissue, the cannabinoid system performs different tasks. But the goal is always the same: homeostasis, the maintenance of a stable internal environment despite fluctuations in the external environment”. Think of the ECS as your body’s ‘root level’ operating system, a kind of central processing unit that regulates and alters the functioning of many other important systems and keeps them in balance.
Martin Lee, author of, ‘Smoke Signals: A Social History of Marijuana’, notes cannabinoid receptors are more abundant in the brain than any other type of neurotransmitter receptor and “function as subtle sensing devices, tiny vibrating scanners perpetually primed to pick up biochemical cues that flow through fluids surrounding each cell … When tickled by THC or its endogenous cousins, these receptors trigger a cascade of biochemical changes on a cellular level that puts the brakes on excessive physiological activity. Endocannabinoids are the only neurotransmitters that engage in such ‘retrograde signaling’ a form of intracellular communication that inhibits immune response, reduces inflammation, relaxes musculature, lowers blood pressure, dilates bronchial passages and normalizes overstimulated nerves. Retrograde signaling serves as an inhibitory feedback mechanism that tells other neurotransmitters to ‘cool it’ when they are firing too fast”.
In a 2006 study published in Pharmacological Review, National Institute of Health researcher Pal Pacher, M.D., Ph.D explained the cognitive leap that took place.
“In the past decade, the Endocannabinoid System (ECS) has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs. Modulating the activity of the Endocannabinoid System (ECS) turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson’s and Huntington’s disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome and osteoporosis, to name just a few”.
But what happens when you purposefully disrupt the body’s ability to stimulate the ECS? Things can go haywire, as discovered when ‘Big Pharma’ tested Rimonabant, an anti-obesity drug designed to create a kind of ‘reverse munchies’ by preventing cannabinoids (endo or phyto) from binding to CB1 and CB2 receptors. Those enrolled in a planned 33-month study of Rimonabant did report lower overall appetite when taking the drug, but they also demonstrated an increased risk of suicide so pronounced that the study was abandoned after little more than a year and four suicides! “Patients taking Rimonabant reported feeling severely depressed and having serious thoughts about committing suicide”, Psychology Today reported. “It was as though the patients had lost their ability to experience pleasure… [Which] tells neuroscientists that our endogenous marijuana* system is normally involved, either directly or indirectly, in controlling our mood and allowing us to experience pleasure; antagonizing the actions of this chemical in the brain leads to depression with possibly dangerous consequences”.
Researching the Truth about Cannabis and Hemp
And yes, here’s hoping for a very hempy celebration season – AnnMaria HempEdification http://hempedification.blogspot.com/
Lately, many people have shared with me how completely exhausted they are for no reason. Many have shared that their doctors say. their endocrine system is out of balance, not working properly and even shut down. This is very concerning since I know our endocannabinoid system and our endocrine system are directly connected. The challenge has been, over the past 80 years, not many people have been ingesting cannabis to feed their endocannabinoid system which balances the homeostasis of the endocrine system. I’m no expert in this field, however, I have learned so much about our internal systems over the past few years in the hemp world that’s I’m excited to continue sharing this information with you.
Becuase we have experts in this area, I am turning to Linda & Tyler Struse to give us even greater detail on this life-enhancing and life-saving discovery! take it all in – Darlene Mea, Producer, HempingtonPost
The Role of the Endocannabinoid System in Restoring the Endocrine System.
written by Tyler Strouse of RandysClub.org
Over the last few years, cannabis and the endocannabinoid system have emerged as a topic of interest among patients and those within the scientific community.
The endogenous cannabinoid system (ECS), named after the cannabis plant that led to its discovery, is one of the most important physiological system involved in establishing and maintaining human health. Endocannabinoids and their receptors, CB1 and CB2, are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. In each tissue, the ECS performs different tasks with the goal of maintaining homeostasis, the maintenance of a stable internal environment despite fluctuations in the external environment.
The endocrine system is the collection of glands in the body that secrete hormones into the bloodstream to be carried towards distant target organs. The central neuroendocrine systems is the interface between the brain and the rest of the endocrine systems. The part of the brain that balances the release of hormones in the body is called the hypothalamus and sits right on top of the pituitary gland where it regulates stress, metabolism, growth, reproduction, and lactation.
All of these processes are regulated by the hypothalamus releasing or inhibiting the release of hormones by the pituitary gland. The release of pituitary hormones affects downstream physiological functions. Other hypothalamic neuroendocrine cells control water/salt balance, and lactation and childbirth, through the release of vasopressin and oxytocin. Together, these hypothalamic neuroendocrine functions enable the central nervous system to respond rapidly to internal or external environmental change, and to maintain a response through endocrine hormonal transducers. The ECS modulates the regulation of the neuroendocrine system, which regulates organ function and stress response and helps maintain a healthy balance across the neuroendocrine system and related physiological body system.
Targeting the Endocannabinoid System for Endocrine Regulation
Cannabinoids in cannabis have long been known to be able to affect the secretion of pituitary hormones. By way of the ECS we regulate our hormonal balance, both up and down, through a direct effect on the organs themselves. The stimulation of the hypothalamic-pituitary-adrenal (HPA) axis is a crucial neuroendocrine response to stress and is dependant on CB1 receptor-mediated signaling. Activating the CB1 receptors in the hypothalamus results in a signaling cascade that ultimately inhibits overall neuroendocrine function. Stress is well known to affect endocrine function and a poorly regulated endocrine system can lead to major health problems. The endocrine response, as part of the HPA axis, is central to its regulation.
Up until a few years ago, the stimulatory effects of cannabinoids on the HPA axis was considered as an exception. The commonly accepted view of the ECS was that it played a general inhibitory role on neuroendocrine functions. We now understand that cannabinoids can have both stimulatory and inhibitory effects on the HPA axis which is how it’s able to modulate its regulation. These biphasic effects of cannabinoids, both stimulatory and inhibitory, are increasingly revealing themselves as we look closer at the interactions between the ECS and the endocrine system.
This brings us to the cannabinoid du jour, cannabidiol or CBD. Long playing the second fiddle to the more active tetrahydrocannabinol (THC), CBD does not interact strongly with either the CB1 or CB2 receptors. Instead, CBD is able to increase endocannabinoid tone by inhibiting fatty acid amide hydrolase (FAAH) and enzyme that breaks down cannabinoids in the body. FAAH inhibitors may be helpful for people with anxiety-related disorders because they appear to improve the regulation of the HPA axis. It’s unknown precisely how this happens, but it appears they help to modulate the sensitivity of the cannabinoid receptors in the body.
In addition to its stimulatory effects on HPA, the ECS also plays a critical inhibitory role in regulating HPA functions. Researchers found that endocannabinoid signaling negatively modulates the stress-induced activation of the HPA axis, confirming the notion that an increase in endocannabinoid signaling activity may constitute a novel approach to improving the lives of people with anxiety-related disorders.
Currently, the best way to boost endocannabinoid signaling, improve the regulation of the HPA,, and promote a healthy endocrine system is the use of a dietary cannabinoid supplement made from hemp. These products contain naturally occurring cannabinoids, including CBD, which have been shown to naturally increase ECS tone which helps to improve the regulation of homeostasis across the HPA axis. This will improve both the physiological and psychological responses to stress making us more likely to resist the cascade that leads to HPA dysfunction and endocrine-related health problems. Enjoy a cannabinoid supplement every day!
Source: Uberto Pagotto, Giovanni Marsicano, Daniela Cota, Beat Lutz, Renato Pasquali; The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance, Endocrine Reviews, Volume 27, Issue 1, 1 February 2006, Pages 73–100, https://doi.org/10.1210/er.2005-0009
‘I, Darlene Mea, producer of HempingtonPost.com have discovered over the past few years ‘we have an endocannabinoid system’ AND CBD is the absolute best food ever for our entire body’. I use CBD daily, it has changed my vitally level immensely’.
The following article is written specifically for HempingtonPost.com from our most trusted source, www.RandysClub.org – We appreciate this company because their dedication is beyond the frenzy of the dollar – it is their mission to help heal the world with cannabis hemp products.
Industrial Hemp:brings together some of the leaders of the industrial hemp movement to discuss their views, research and experience.
View this outstanding publication
The articles range from poetry by Native American activist John Trudell to an interview with David Bronner and Will Allen as they reminisce over being arrested for protesting in front of the DEA offices against the fact that industrial hemp is still considered to be a Schedule I substance. Established contemporary artists Karen Gunderson and Glenn Goldberg create work from and about hemp while Mitch Epstein, one of the finest photographers of his generation, takes a stunning cover portrait of Alex White Plume wearing his grandfather’s feather bonnet.
Mia Feroleto, producer and creative director of HEMP NY CITY, edits this collection to share what is and the possibilities of what can be with industrial hemp.
1. Eric Steenstra, Executive Director of Vote Hemp on the history of industrial hemp and the industrial hemp movement
2. Joel Stanley, CW Botanicals
on the creation of Charlotte’s Web
3. Michael Carus, Nova
board member of the EU Industrial Hemp Association
on hemp in the EU
4. Jeffrey Silberman, Chairman of the Sustainable Textiles Department at FIT on hemp textiles
5. Will Allen, farmer and activist, named one of the 50 most influential people by Politico; and David Bronner of Dr. Bronner’s Magic Soap
on their experience in the hemp movement as activists
6. Glenn Goldberg, artist
on his experience at Dieu Donne making hand made hemp paper works
7. Mike Lewis, founder of Growing Warriors and hemp farmer in Kentucky
on farming hemp and the founding of Growing Warriors
8. Heather Jackson, Executive Director of The Realm of Caring Foundation,
on her personal experience
9. Steve Allin, builder, on building with hempcrete around the world
10. Michael Reif, attorney, and Marcus Grignon, farmer and activist, on Native American issues with farming hemp
We are thrilled to share this excellent interview with Tyler Strause, Founder & President of RandysClub.org.
Enlightening, This interview is informing, inspiring and engaging, you will definitely find your time well spent!
A scientist at heart as well as a dedicated activist for this legacy industry of Cannabis/Hemp/Medicinals Strause knows what he talking about, it’s his life’s passion. I need say no more, listen UP!
we’re making Cannabis History!
Tyler Strause interviewed on The Cannabis Entrepreneur Show
This interview with Tyler allows us to gain a greater understanding as we emerge into this mega transitional Cannabis industry paradigm! ‘We are moving from unregulated to regulated. It’s important to discover and understand the truth within the Cannabis Hemp world while being aware of the rules of this game-changing industry…there are many rules & regulations!
The Strause Family work as a symbiotic unit with RandysClub
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We hope you enjoy and become more enlightened just from tuning in- I know I did!
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When choosing CBD for health, it’s good to be on alert and do your research. It’s not easy when there are so many variables in the CBD industries. We at HempingtonPost have a little help from our trusted business associates, while doing our own do-diligence, This is how and why Hempington Post is building our Trusted HEMP Product Marketplace with Made in America and Made with Integrity Hemp Products!
Comments from Robert Cronin of Red LLama Trading
Interesting study of oils from Europe. Turns out that only about 1/3 are safe and even that is suspect. Big problem is labeling: i.e., what is CBD oil from Hemp, and what is Hemp oil. Hemp oil is from hemp seeds, not the plant, and has no CBD’s in it. None. CBD oil from what is CBD oil fHemp, according to the US Gov and what they allow to be imported, MUST be from the stalk and the hart, not the flowers or leaves, and only from male plants not female plants. That, they say, is illegal to import.
A concurrative problem is the content of THC; often more than the allowable limits. I suspect that may be that European growers are starting to make their oils from female hemp plants doing full plant extraction. The female has more CBD and other cannabinoids. BUT, it also has more THC! This oil should is not legal to be imported since it is exactly against US Custom regulations, but it is being imported. It will continue until legality issues are resolved here in US.
the below article was reviewed and commented on by Robert Cronin
Founder / Chief Executive Officer
Mobile: (760) 218.6543
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Independent Testing of European CBD and Hemp Oils Leads to Alarming Discoveries
May 25, 2017 by Pavel Kubu 0 Comments
Independent testing on the quality and composition of CBDs and hemp oils offered on the European market has confirmed substantial deficiencies – and possibly even risks to consumers.
Results clearly indicate the need to introduce precise standards for the safe production and distribution of cannabis-based products – and systematically monitor their adherence.
The historically first independent testing of hemp oils and certain types of commercially available CBDs (i.e. materials from cannabis having no psychotropic effects) has taken place in cooperation with the University of Chemistry and Technology in Prague (VŠCHT). Here, in the framework of the Department of Food Analysis and Nutrition, is Europe’s first laboratory certified by the Patient Focused Certification program also being used in training by Americans for Safe Access in the U.S.
The team led by Professor Jana Hajšlová tested a total of 29 oils containing cannabidiol and another 25 oils extracted from hemp seeds. All tested products were purchased on the European market in the last quarter of 2016. The International Cannabis and Cannabinoids Institute (ICCI), headquartered in Prague, Czech Republic, performed the final assessment of the results.
Besides verifying whether the content of CBD stated by the producer on the packaging truly reflects the reality, the quality of cannabis-based foods was assessed chiefly on the basis of two key criteria. The first to go under the microscope were multi-nuclear polycyclic aromatic hydrocarbons (e.g. benz(o)pyrene), which the International Classification for Cancer Research ranks among carcinogens. The ICCI director of research, Tomas Zabransky, warned: “These are substances whose carcinogenicity was proven experimentally on animals, and it has been proven in a great number of epidemiological studies. Mainly for ill persons trying to take advantage of the known beneficial effects of CBD, these hydrocarbons are undeniably dangerous, mainly upon long-term use.”
The second aspect that was given special attention during chemical analysis was the content of tetrahydrocannabinol – THC. “THC is another medically active substance from cannabis, but as opposed to CBD it is psychoactive,” Zabransky said. “So even relatively low amounts can cause changes in perception among more sensitive individuals, which can threaten their capacity to drive and make decisions in general – especially in case of being unaware of the possibilities of influencing one’s psyche by an external substance. Another problem among drivers could be testing positive during traffic controls, which can lead at the very least to losing one’s driving privileges.”
So what results did the analysis uncover? Worse results than the initiators themselves expected. In terms of the content of polyaromatic hydrocarbons, which can help cancerous growth, only 9 of the 29 tested CBD oils were satisfactory.1 That’s less than one third.
A bit better off were those hemp oils, which in reality came from seeds and not the plant. In this category, legislative limits were met in a full 92 percent of the 23 tested products.
The analysis also uncovered gaps in information that producers provide to customers regarding the composition of the product. Of 10 tested CBD oils, six did not state any THC content. This finding is alarming, especially when the consumer can realistically be punished for exceeding the permitted level of THC in the blood – whether during traffic stops or at work.
For a fourth of the tested oils, the user can be unknowingly exposed to this risk even when using the recommended dose. For another 10 percent of oils, this risk exists in relation to using the maximum dose stated on the packaging.
What comes next? The ICCI are contacting all manufacturers of tested cannabis foods, share the results and offer help when checking the safety and increasing the quality of the product. The list of those foods satisfying the limits in the analysis is available to all consumers at the website of PFC International.
Information will be provided to members of patient organizations associated in the international association IMCPC by means of the society KOPAC regarding the quality of a specific oil they are using, as to whether it was among those tested, and if so, with what results.
Filed Under: International
Tagged With: CBD, European market, hemp oils, THC content, The International Cannabis and Cannabinoids Institute (ICCI)
About The Author:
Pavel Kubů is the CEO of the International Cannabis and Cannabinoids Institute (ICCI). He is an expert in the fields of medical informatics and addictology. In 2001, he graduated in general medicine with a focus on disease prevention and public health from the Third Faculty of Medicine, Charles University. Since 2005 he has been working for the Intel Corporation as a Business Development Manager, leading projects of the Intel World Ahead Programme for Healthcare in Central and Eastern Europe and Education in the Czech Republic and Slovakia. In 2006 he was appointed as chair of the Ethics Commission at the National Monitoring Centre for Drugs and Addiction. Pavel has served since 2007 as a board member of the Czech National Forum for eHealth, from 2012 to 2015 as a member of the steering committee of the Czech Healthcare Forum and since 2013 as a board member of the medical cannabis patients’ organisation KOPAC. In these non-profit NGOs he is primarily devoted to the education of healthcare professionals, patients and caregivers and support for the research and development of new treatment and preventive methods. Since 2011 he has led the implementation of medical strategy at the company ELON MEDICAL s.r.o., devoted to wearable plastic electronics for new treatment methods using printed light devices. In 2014 he became a cofounding member of Konomed s.r.o., a company that focuses on research and development in the field of medical cannabis.