Big Pharma In Outrage Over Willie Nelson’s CBD: Complete Strength CBD – He Fires Back With This!

Big Pharma In Outrage Over Willie Nelson’s CBD: Complete Strength CBD – He Fires Back With This!

In an emotional 1-on-1 interview, one of America’s most respected icons revealed that he wouldn’t be where he is without CBD.

We all know and love Willie Nelson as the charismatic country star who has never been shy about advocating for marijuana use. He has always been focused on creating music, going on tour, and promoting America. However, he shocked everyone when he announced his new CBD line, Complete Strength CBD, would be the next step in his career.

In recent developments, Willie revealed that he would be stepping away from the spotlight to put more time into his wellness business, now that it has grown so fast:

“This was a really, really difficult decision for me. When I started this whole thing back in 2015, it really was just a part time passion project and a way for me to give back. Now here we are almost 5 years later and Complete Strength CBD has steadily grown into a full-fledged business that’s helped thousands of people become pain free and much happier. My line gives me a chance to do something bigger than music and I knew I would regret it for the rest of my life if I let that opportunity pass me by.”

Willie went on to say that he never really expected things to get this big and that several studios and sponsors were furious that he was splitting up his time. In fact, relations with some studios grew so tense that they ended up giving him an ultimatum – singing or his wellness line.

He knew he would receive scrutiny from fans and sponsors for quitting, but he felt it was time to work on something that would positively change the lives of millions of people.

The product Willie is referring to is his breakthrough CBD wellness line Complete Strength CBD. The star has spent the past four years developing a line of highly effective and highly potent wellness products that he claims are the solution for those who don’t want to resort to using opiates.

His product Complete Strength CBD sold out within ten minutes when first launched and it seems the world can’t get enough of the benefits and results.

Willie even admitted that big pharma companies are furious with him  after noticing a large decline in sales since Complete Strength CBD was launched on the market.

“Users of Complete Strength CBD are experiencing results that before now were only possible through prescription medication. It’s obviously a much cheaper, and safer alternative and because of that pharmaceutical companies are finding it harder to keep patients using their prescriptions.”

Having a crowd of angry pharmaceutical companies is a unique and effective endorsement for Complete Strength CBD, but Willie has still been proactive in getting Complete Strength CBD into the hands of those who need it.

Complete Strength CBD has been found to have a positive impact on key body functions including – neurological, physical, and psychological.

This includes but not limited to:

  • Reduces Chronic Pain
  • Supports Joint Health
  • Reduces Anxiety
  • Reduces Headaches
  • Reduces Blood Sugar
  • Supports Cognitive Health
  • Antioxidant Support

While making an appearance on ‘Fox’ he gifted the cast and crew with Complete Strength CBD products and made sure every guest was given a sample of the life changing supplement. Since then, he has cultivated a huge celebrity clientele who are regularly reordering the products. See for yourself!

This story first appeared at The Misanthrope London

Hemp the Superfood

Hemp the Superfood

Even though many are moving toward CBD for its health benefits, the market is still crazy and confusing. Perhaps it’s time we all take a closer look at Hemp protein and Hemp seeds as the superfoods that they are. Discover the easy and logical way to give our body more balance nutrients from one source. Hemp is the power booster to reboot our bodies immune system engine! Btw – hemp smoothies are off the charts tasty with Hemp milk and your favorite fruits!

Hemp is made for human consumption which has become obvious just recently when we found out, in the last five years, we have an endocannabinoid system with receptors for cannabinoids! Who knew? We certainly didn’t know, and now, we do. Why wait to hemp up our endocannabinoid system when we have completely legal Hemp, Hemp proteins and Hemp seeds at our fingertips. *be sure to go with reputable companies for your products andread the ingredients!

These small, brown seeds are rich in protein, fiber, and healthful fatty acids, including omega-3s and omega-6s. They have antioxidant effects and may reduce symptoms of numerous ailments, improving the health of the heart, skin, and joints.

Although hemp seeds come from the Cannabis sativa plant, they do not produce a mind-altering effect.

In this article from Medical News Today, we look at the various benefits of hemp as a superfood.

Nutritional benefits of hemp seeds

Protein

Benefits of hemp seeds

Hemp seeds are a complete source of protein, providing all nine essential amino acids.

Hemp seeds contain almost as much protein as soybeans. In every 30 grams (g) of seeds, or about 3 tablespoons, there are 9.46 g of protein.

These seeds are a complete source of protein, meaning that they provide all nine essential amino acids. Amino acids are the building blocks for all proteins. The body cannot produce nine of these acids, so a person must absorb them through the diet. Relatively few plant-based foods are complete sources of protein, making hemp seeds a valuable addition to a vegetarian or vegan diet. Hemp seeds are especially rich in an amino acid called arginine, which has benefits for heart health.

Hemp contains an extensive list of naturally occurring vitamins, including vitamins A, C, and E. Also present are B complex vitamins like riboflavin, thiamine, and niacin. Hemp further contains vitamins that are not sufficiently present in most modern diets, like beta carotene, helping users gain the nutrients they need to maintain health. Hemp is likewise a source of minerals like zinc, potassium, calcium, phosphorus, iron, and magnesium.

Protein in your diet is essential in the receiving of amino acids, but it’s important that we obtain protein from the right sources. Eating even small amounts of red meat has been warned against by health officials. Instead, essential amino acids can be obtained through plant sources like hemp, which contains all 20 amino acids – including the 9 essential amino acids our body can’t make on its own.

The one fat you can never get enough of is Omega 3, but modern diets typically use other, less healthy fats. While both Omega 3 and 6 fatty acids are essential to human health, they should ideally be consumed at a close ratio of around 3:1. Eating the right kind of Omega 6 fatty acids, like gamma-linolenic acid (GLA), a plant-based Omega 6 fatty acid found in hemp at the 3:1 ratio suggested, can reduce the negative effects of high-fat diets.

The shelled seeds of the hemp plant contain about 35 percent essential fatty acids and 33 percent plant protein. They are also rich in soluble and insoluble fiber. These high levels of protein, fiber, and healthy omega fatty acids mean that using hemp foods can benefit you by helping aid proper digestion and promoting healthy eating patterns, which may lead to weight loss. 

Hemp seeds contain an impressive array of vitamins and minerals and are especially rich. According to the USDA National Nutrient Database, one tablespoon or 30 grams of hemp seeds contains:

  • 166 calories
  • 9.47 g of protein
  • 14.62 g of fat
  • 2.6 g of carbohydrates (including 1.2 g of fiber and 0.45 g of sugar)
  • 21 mg of calcium
  • 2.38 mg of iron
  • 210 mg of magnesium
  • 495 mg of phosphorus
  • 360 mg of potassium
  • 2.97 mg of zinc

Healthy Benefits

Protect the brain

Benefits of hemp seeds brain

The CBD compound found in hemp seeds may help with neurological conditions.

A study published in the journal Food Chemistry found that hemp seed extract has antioxidant effects in lab tests. These effects may result from the seeds’ cannabidiol (CBD) content.

Results of a review from 2018 suggest that CBD and other compounds in the seeds may have neuroprotective, anti-inflammatory, effects and may also help to regulate the immune system.

The review suggests that, because of these potential properties, CBD may help with neurological conditions, including:

Boost heart health

The medical community believes that omega-3 fatty acids improve the health of the heart and reduce the risk of issues such as arrhythmias and heart disease.

Hemp seeds contain high levels of omega-3s and a healthful ratio of omega-3 to omega-6 fatty acids.

The seeds also contain high levels of arginine, an amino acid that turns into nitric oxide.

Nitric oxide is essential for artery and vein dilation, and it helps keep blood vessel walls smooth and elastic.

Lowering blood pressure, eating a healthful diet, and participating in varied forms of exercise may help to decrease the risk of heart failure.

Reduce inflammation

The amount of omega-3s in hemp seeds and the seeds’ healthful omega-3 to omega-6 ratio can together help to reduce inflammation.

In addition, hemp seeds are a rich source of gamma-linolenic acid (GLA), a polyunsaturated fatty acid which may also have anti-inflammatory effects.

Some studies on animals suggest that GLA can act as a potent anti-inflammatory. However, recent studies in humans suggest that the acid is not always effective.

A review in The European Journal of Pharmacology states that humans process GLA in a very complicated way, which may explain why the studies in humans produce more varied results than those on animals.

When looking at these studies, it is important to note that researchers usually use high concentrations of hemp seed extracts and that eating the seeds may produce less dramatic effects.

Reducing inflammation may help manage the symptoms of chronic diseases, such as:

Improve skin conditions

Atopic dermatitis (AD) and acne can both result from chronic inflammation. The anti-inflammatory compounds in hemp seeds may help.

Among other possible dietary causes, acne may be linked to a deficiency in omega-3s. The high omega-3 content in hemp seeds may help to manage and reduce acne symptoms.

2018 review explored the effects of dietary changes on skin diseases. While the authors found evidence that eating more omega-3s may improve symptoms of acne, determining the extent of the effects will require more research.

The authors also note that prebiotics and plant fibers may help to manage symptoms of AD. Hemp seeds are a rich source of plant fiber.

Relieve rheumatoid arthritis

Rheumatoid arthritis is an autoimmune condition. It causes the immune system to attack its own tissues, which leads to inflammation in the joints.

In 2014, research conducted in human cells suggested that hemp seed oil could have anti-rheumatic effects.

However, a 2018 review found a lack of conclusive evidence to suggest that cannabinoids could effectively treat rheumatic diseases. The authors noted that more research is needed.

Note from the Publisher, darlene mea:

Why wait for healthy? If it is our intent to get back to healthy, Hemp seeds and Hemp Protein is a powerful way to re-boot our engine! Let me know how it goes?


Could Endocannabinoid Deficiency Syndrome Be the Cause of IBS and Migraines?

Could Endocannabinoid Deficiency Syndrome Be the Cause of IBS and Migraines?

A small group of scientists and doctors believe a lack of endocannabinoids could explain the causes behind little-understood medical conditions like fibromyalgia, IBS, and migraines.

Cannabis seems to treat an impressively wide range of medical conditions, from chronic pain to eating disorders to depression to cancer. Researchers suggest that weed may appear to be a universal panacea — a miracle drug, if you will — because the plant’s compounds may help maintain our body’s endocannabinoid system

A refresher: The endocannabinoid system is a physiological system like the respiratory system or the nervous system. Although scientists only discovered it about three decades ago, it may be one of — if not the —  most important developments in medical history. 

The endocannabinoid system regulates our body’s homeostasis, a state of harmonic balance where everything works as it should. It’s also key to our nervous system’s ability to communicate with other cells, tissues, and organs. Learning, memory formation, appetite, immune response, and healing are all controlled by the endocannabinoid system. Think of it as the part of our bodies that connects the brain with everything else, both inside of us and out in our surrounding environments. Without this system, the evolution of ‘higher’ lifeforms likely wouldn’t have happened (at least, not according to our current understanding of biology).

“We all have an endocannabinoid system,” said Robert Melamede, PhD, during a recent talk at Harvard University. Melamede is a molecular biologist and cannabis activist who’s served as a scientific advisor to NORML and other cannabis advocacy groups. 

“The miracle of this is that the endocannabinoid system regulates everything in your body — immune, digestive, cardiovascular, skin, bone, reproductive — from your conception until your death.”

To self-regulate the endocannabinoid system, our bodies naturally produce chemicals called endocannabinoids (endo- for “inside” and –cannabinoid for “related to cannabis”). Two of the most studied endocannabinoids are anandamide and 2-AG, which interact with the same cannabinoid receptors on our cells that plant cannabinoids such as THC and CBD also act on. 

Cannabinoids bind to cell proteins called cannabinoid, or CB, receptors. CB receptors act as locks on a cell, and cannabinoids essentially unlock them to trigger cell signaling. One of these receptors, CB1, mainly resides in the nervous system. Another receptor, CB2, can be found in the spleen and on immune cells.

THC, the cannabis compound that gets people stoned, binds tighter to CB1 receptors in the brain than it does to CB2 receptors in the immune system. This may be why THC couch-locks tokers and CBD doesn’t.

If we take this model a step further, anandamide may be our body’s version of THC, whereas 2-AG could be the body’s version of CBD. How do we know? Anandamide and 2-AG both bind to the CB1 and CB2 receptors, but anandamide binds better to CB1 (like THC) and 2-AG binds best to CB2 (like CBD).

Raphael Mechoulam, PhD, the “godfather of cannabis science” who first isolated and characterized THC in the late 1960s, believes anandamide behaves just like THC in the body. He suspects that anandamide, administered in the correct amounts, could even generate a “high” identical to THC’s, though, to date, no human subjects have been given pure anandamide to test this out. 

According to one neurologist, certain medical conditions — namely fibromyalgia, migraines, and irritable bowel syndrome (IBS) — share one thing in common: the patients typically exhibit low endocannabinoid levels. Furthermore, these three conditions are comorbid, meaning patients diagnosed with one usually have another, if not all three.

In 2001, while working as a scientific advisor to GW Pharmaceuticals, Dr. Ethan Russo first proposed what he calls “clinical endocannabinoid deficiency,” or CECD, in a paper about migraines. In recent years, this term started going by another name, “endocannabinoid deficiency syndrome,” or ECDS (Russo prefers the former). Both terms refer to the same hypothetical condition.

What is endocannabinoid deficiency syndrome, and what are its symptoms? Many of the details are still being worked out, but chronic pain, rampant inflammation, insomnia, fatigue, depression, lack of appetite, and irritability are common issues associated with it.

Rather than being a disease that always triggers a specific set of symptoms, ECDS may manifest differently among patients, depending on their environments, lifestyles, diets, and genetic make up.

But what if there’s more to this? What if these various maladies are all connected somehow? And what if cannabis, by restoring endocannabinoid function, could successfully treat conditions caused by low endocannabinoid levels, conditions that have proven difficult, if not impossible, to control through conventional medicine?

A Medical Diagnosis Based on the Body’s ‘Natural Marijuana’

Initially, Russo suggested that migraines could be caused by low anandamide levels in the brain. Because sharp, throbbing pains always accompany migraines, research suggests a pain-killing compound like anandamide could keep them at bay. Both anandamide and THC — the intoxicating part of cannabis — activate the endocannabinoid receptors in our nerves. In other words, migraine patients who consume marijuana may be self-medicating by adding the plant’s version of anandamide back into their bodies.  

Since Russo first proposed endocannabinoid deficiency syndrome, its related disorders expanded to include several other ailments. And their causes have eluded medical science, not unlike fibromyalgia and IBS. But given news that medical schools didn’t teach their students about the endocannabinoid system until the last few years, is the medical community even aware of this syndrome?

“There’s an awareness of this condition, and it is getting noticed. And there’s a good deal of research that’s been done on it,” Russo told MERRY JANE over the phone. “What’s happened in the ensuing 18 years [since proposing ECDS/ECDS] is we’ve gradually built up objective evidence showing that people with some of these syndromes [like IBS or fibromyalgia] do have differences between their endocannabinoid content either in their blood or in the cerebrospinal fluid in their brain.”

Russo cited a few eye-opening studies that back him up. One 2013 paper looked at people diagnosed with PTSD shortly after witnessing (or outright experiencing) the 9/11 terrorist attacks in New York. Serum analysis showed these patients produced less anandamide and 2-AG, which are both crucial for regulating stress responses.

Additional studies confirmed that constant stress dulls the endocannabinoid receptors from responding to chemical signals, which may explain why the body reduces its anandamide and 2-AG production when life gets extremely difficult.

Researchers have also detected abnormal endocannabinoid function in people with autism spectrum disorder, some cancers, motion sickness, and epileptic seizure disorders. These conditions, like migraines, can be treated with cannabis, too.

How does ECDS explain these disorders, and how can cannabis treat them? Let’s take a look at one endocannabinoid deficiency-related condition, irritable bowel syndrome, to get a better understanding of how cannabis could treat it on multiple levels.

IBS and ECDS: How Are the Conditions Related?

Irritable bowel syndrome or irritable bowel disorder is a common ailment that affects anywhere between 25 million to 45 million Americans. Two-thirds of IBS patients are female, and the condition appears in patients across all age groups. 

IBS’s symptoms include bloating, digestive inflammation, rampant flatulence, upset stomach, diarrhea at random hours (especially in the middle of the night), constipation, ulcers, and a hypersensitivity to all sorts of everyday foods and food additives. Untreated, IBS can lead to anemia, iron deficiency, or dehydration. 

The symptoms of IBS have been thoroughly identified, but how it happens remains a mystery. Doctors know that genetics, immune response, serotonin dysregulation, and the digestive system’s microbiota all play a role. But to what extent these factors influence IBS, and how they’re all connected, is unknown.

Enter a new perspective on IBS, one viewed through the lens of ECDS.

According to Russo, the endocannabinoid system regulates every level of IBS, from anti-inflammatory signals to serotonin signaling to maintaining the delicate balance of bacteria in the gut. Traditional medicine takes an inefficient approach to dealing with IBS. Doctors typically treat it by prescribing drugs for its various symptoms: a pill to reduce the gas and bloating, another pill to reduce inflammation, another pill to reduce gastric acid, another pill to make the ulcers go away, a laxative for constipation, and so on.

Yet, if ECDS can explain why IBS even happens, then consuming some cannabis could both replace all those pills and correct the condition’s root cause, a dysfunctional endocannabinoid system. 

Medical syndromes, like the proposed ECDS, are not disease-states in and of themselves. Rather, they describe a set of symptoms that share underlying causes, usually genetic in nature. Since the genetic science behind endocannabinoid activity is still in its infancy, endocannabinoid deficiency syndrome remains hypothetical. Doctors can’t diagnose it because it’s not officially recognized by the big-name medical associations.

If the science pans out, and Russo’s hypothesis is proven correct, then cannabis could be one of the most prevalent and effective medicines for treating ECDS and its related conditions. Depending on where the research takes us, it’s possible that cannabis breeders could produce new marijuana strains tailored to endocannabinoid-deficient conditions like fibromyalgia or IBS. 

Of course, pharmaceutical companies will want in on the game, too. (Just kidding: They’re already in the game.) Pharmie-grade mixtures of less common cannabinoids — like CBG, CBN, or THCV — could alleviate the chronic symptoms of fibromyalgia, migraines, IBS, or other issues related to ECDS that conventional pharmaceuticals have failed to treat.

And it’s also possible that new drugs or designer weed may not be necessary for avoiding some endocannabinoid deficiencies. Researchers like Robert Melamede believe endocannabinoid deficiency can be prevented by adding more omega-3s and plant-derived cannabinoids to one’s diet.

“We should view cannabis not as a medicine, but as an essential nutrient,” Melamede said during the Harvard lecture. “Every illness that cannabis helps reflects a nutritional deficiency.”

Supplementing a balanced diet with omega-3s helps the body produce more endocannabinoids — which is why doctors and health-nuts promote omega-3s, even if they don’t know why, exactly. Omega-3 fatty acids, such as those found in avocados, coconut oil, grass-fed beef, and fish, are the precursors to our own endocannabinoids. Our body basically makes its own weed from healthy fats. 

But the body can only produce so many endocannabinoids at a time, regardless of how many fish oil capsules you pop. For those who suffer from persistent endocannabinoid deficiencies, consuming cannabis could make up for the gaps, since the cannabinoids in cannabis could, potentially, supplement the body’s life-sustaining endocannabinoids.

What Would It Take for ECDS to Become a True Diagnosis?

So let’s assume that ECDS is a real thing. How would medical scientists get the syndrome into medical textbooks?

“There’s abundant evidence now, but it’s not widely recognized or necessarily accepted by the medical community,” Russo said. Achieving said recognition may prove difficult, as he described the same medical community as one “which has managed to ignore a lot of high-quality work on cannabis-based medicines.”

As an example of American medicine’s denial of marijuana’s therapeutic potential, Russo mentioned Marinol, a synthetic THC formulation used to treat spasticity and nausea. Marinol doesn’t contain THC extracted from the cannabis plant. Rather, its active ingredient is a purely artificial, human-made version of THC. The drug, which received FDA approval in the early 1990s, is currently classified as a Schedule III drug, whereas plant-derived THC remains at the most-restrictive category of Schedule I. This is despite the THC in Marinol being nearly identical, chemically, to the THC found in cannabis.

“To be honest,” he continued, “given the availability of Marinol in the US, a prerequisite to [getting ECDS recognized] would be clinical trials showing safety and efficacy [of cannabinoid-based medicines]. That’s what most physicians would accept.”

In other words, if you’re waiting to get a medical cannabis recommendation for ECDS, you might have to wait a few years. Or more. With the exception of experimental drugs admitted into the FDA’s Fast Track program, it can take nearly a decade before a pharmaceutical receives FDA approval. Even with Fast Track designation, drug approval can require years of investigation. With cannabis-based medicines containing plant-derived THC, approval could take even longer.

For starters, clinical trials aren’t simple to conduct. Research doctors must apply to the FDA to legally perform the trials on living, breathing human subjects. To even get to the point of testing something on people, drug researchers must pass preliminary clinical trials on animals like rats or monkeys. 

If a cannabinoid medicine appears safe in animals, doctors can potentially try it on humans, but only after receiving FDA approval — which the FDA can be pretty stingy about, especially when it comes to cannabis. To date, the FDA has only approved one drug made from cannabis, Epidiolex, which is only prescribed to seizure patients. All other CBD products sold in the US are not FDA-approved nor are they regulated by any federal agency. 

However, there’s another cannabis-derived pharmaceutical out there, Sativex. Sativex, made by the same company that made Epidiolex, GW Pharmaceuticals, is a mixture of THC and CBD. While it’s available in Europe, parts of Asia, and the Middle East, it’s not available in the US. In 2017, the CEO of GW Pharmaceuticals told MERRY JANE that the company didn’t pursue FDA approval for Sativex in the US because there were too many bureaucratic hurdles, and Sativex likely wouldn’t receive FDA approval in a timely manner simply because it contains plant-derived THC.

On top of obstructionist red-tape, conducting clinical trials is incredibly expensive. Just testing a medicine can cost anywhere from $2 million to over $300 million.

Until medical science achieves a better understanding of the endocannabinoid system and any ailments related to its dysfunction, Russo recommends plant-based therapies instead of pharmaceuticals like Marinol.

“Throughout my career, I’ve always favored whole-plant extracts over isolates,” he said. “We have Marinol, but THC alone is a lousy drug. It’s never been popular or widely used.”

What’s the big difference among whole-plant cannabis products and all the others, like isolates? As Russo explained in this 2006 paper, any cannabinoid delivered in relative isolation — whether it’s a THC-loaded shatter wax or a pure CBD tincture — doesn’t provide the benefit of the thousands of other beneficial cannabis plant components. In terms of THC vs. CBD, studies show CBD is far more effective when combined with THC. And as Russo noted above, THC alone, regardless of whether it came from the plant or a lab, doesn’t seem to work well unless combined with CBD, either. 

According to Russo and other cannabis researchers, such as Raphael Mechoulam, cannabis operates through an “entourage effect,” sometimes referred to as the “ensemble effect.” Under the entourage model, all of the plant’s cannabinoids, terpenes, flavonoids, enzymes, and other components work together to heal the body. Conventional pharmaceutical science prefers to isolate an individual chemical from a plant, package it, then sell it as a drug. Suggesting that patients smoke buds or take drops of full-extract cannabis oil (FECO) runs counter to US pharmaceutical regulations, which requires all medicines to be made with specific doses of individual chemicals. 

Another Doctor’s Take on ECDS

Russo has studied cannabis as a medicine for over two decades, and ECDS is a theory that could change medicine forever. However, not every doctor is convinced it’s real, and — as Russo himself said — they want to see more data, evidence, and models.

Dr. Zareth Irwin is an emergency medicine specialist based in Portland, Oregon. Although he’s skeptical of ECDS being a true syndrome deserving of an official diagnosis, he says more research could change his mind.

“Different people are affected differently by abnormal levels of potassium or other substances in their body,” Irwin wrote to MERRY JANE in an email. “Making things more difficult in this case, we don’t have good lab assays to easily measure the levels of the endocannabinoids in the body, and have yet to determine all the effects these substances even have on the body.”

Since chemists don’t have reliable methods for accurately measuring endocannabinoids, “we can only postulate whether a deficiency syndrome exists,” Irwin continued. “It certainly may, but I would reserve judgment at this point. I think the argument remains somewhat theoretical.”

Irwin admitted he’s not an expert on endocannabinoid deficiency since his main focus is working in emergency rooms. He does, however, have experience with another cannabis-related syndrome, one possibly caused by too many cannabinoids in the body — cannabinoid hyperemesis syndrome (CHS), the ‘mysterious’ vomiting illness seemingly triggered by heavy cannabis use. 

Irwin said he sees patients with CHS visit his ER every week. While medical research hasn’t caught up to CHS’s underlying causes, or even how to treat it, he approaches CHS like any other disease-state recognized by modern medicine.

“It seems like a leap,” he said regarding the ECDS links among fibromyalgia, migraines, and IBS. “But then there’s another disorder, cannabinoid hyperemesis syndrome, one that I don’t understand on a molecular level, but I believe in it and treat it.”

So, for now, it looks like we have two hypothetical medical disorders related to endocannabinoid function. In the case of ECDS, the body produces too few of the essential endocannabinoids required for normal neurological functioning. To treat it, doctors could feasibly supplement a lack of anandamide with THC, anandamide’s closest relative outside of the human body (chemically speaking).  

In the case of CHS, overstimulation by phytocannabinoids could wreak havoc on natural endocannabinoid signaling. Until science devises a better way to clear phytocannabinoids from the body, the only treatment for CHS may be complete cessation of cannabis consumption, which isn’t exactly ideal for medical patients who only find relief from weed. 

Given the endocannabinoid system’s role in everything from protecting our brain cells to nurturing hunger responses in nursing infants, it’s no surprise that if this system gets out of whack, it could lead to disease-states or medical disorders. Unfortunately, modern medicine — particularly in the US — has skeptically disregarded medicinal cannabis while maintaining its ignorance of the endocannabinoid system. Top-tier medical schools didn’t teach their students about the endocannabinoid system until recently, where the curricula practically glances over the topic.

Countries with liberal drug research laws may blow past the US, regardless of how long it takes America to catch up to the science. Geneticists in IsraelCanada, or Spain may be among the first to unravel many of the mysteries surrounding endocannabinoid-deficient conditions, but phytocannabinoid therapies tailored to treating ECDS probably won’t appear until the cannabis genome is mapped first.

The human genome, on the other hand, has been mapped for a while now. Could the coming era of customized medicinal genomics, where doctors develop treatment regimens for patients based on the patient’s personal genetic makeup, find itself collaborating with the newer science of cannabinoid therapies? Could treating endocannabinoid deficiency lead to a fresh, more comprehensive understanding of medicine altogether?

And what if, one day, a national recreational marijuana market merges with the medical, as we (sort of) saw in Washington State? Hell, we’ve already got weed-infused beer. Could we see, in a far-off future, women chugging a cannabis cream ale to not only get faded, but to also get rid of the cramps brought on by their fibromyalgia and IBS, too? 

This story first appeared on Merry Jane. Follow Randy Robinson on Twitter

5 Benefits of Juicing Cannabis You Probably Didn’t Know

5 Benefits of Juicing Cannabis You Probably Didn’t Know

Most people know you can smoke marijuana and ingest CBD oil, but did you know you can juice the leaves (and not get high)?

Did you know? In addition to providing valuable medicinal and stress-relieving benefits when ingested and smoked, the marijuana plant can be used for everything from making clothing and fireproof construction materials to paper, biofuel, and plastic that decomposes in a timely manner. There’s one application of cannabis few know about or use, however, and that’s juicing the green leaves.

The notion might sound weird or gross at first, but we assure you that there are a number of benefits to juicing cannabis leaves you won’t want to miss out on. Five of the best follow:

1) You won’t get high from juicing and drinking the leaves

Let’s face it, smoking cannabis isn’t for everyone. However, even those that don’t want to toke can agree on the fact that there are numerous medicinal compounds provided by the plant. For this reason, juicing cannabis leaves might be deemed an excellent idea.

Reportedly, juicing raw cannabis provides one with a bounty of chlorophyll, bone-building minerals, terpenes, CBD (medicinal component proven to “cure” cancer), and other cannabinoids) – all without a strong psychoactive effect. Leaf Science elaborates,

“Since heat is required to convert the THCA [THC-acid] in raw cannabis into THC, its psychoactive form, juicing provides a way of obtaining many of the benefits of cannabis without getting high.”

2) Patients can consume higher doses

Those who are battling cancer or seek relief from seizures and/or conditions such as Parkinson’s are likely to benefit from introducing cannabis oil into their regime. Another method of ingesting compounds of the plant, however, is juicing the leaves and this can be just as – or even more – beneficial to the patient.

According to Dr. William Courtney, the founder of Cannabis International Foundation,

“THC can be taken in doses of hundreds of milligrams when in its acid form (juiced). However, once heated, the tolerable dose drops to 10 mg a day.”

In summary, one can consume more of the plant when it’s ingested in a juiced form.

3) Juicing a cannabis bud WILL make someone high

If someone desires to get high but does not smoke or prefers to avoid smelling like the herb, they can juice the flower of the plant to experience a psychoactive trip. One might choose to do this because they have respiratory issues (there are presently no adverse health effects associated with smoking marijuana) or because they prefer to ingest it in a least-harmful method.

As David Wolfe points out, consuming a cannabis flower in juiced form will get someone high, as the two major cannabinoids in the plant exist almost entirely in an acid form. These are known as  Tetrahydrocannabinolic Acid (THC-A) and Cannabidiolic Acid (CBD-A) or “THC-acid” and “CBD-acid.” 

“When these acidic cannabinoids are heated, they are decarboxylated which means they lose their carbon dioxide molecule and become more active. During that process, the cannabinoids change from the acid form to the activated form.  This happens automatically when cannabis flower buds are smoked or vaporized. This also occurs when the cannabis is cooked in coconut oil, olive oil, or ghee even over low heat.”

THC is the component that may result in the user feeling “high” and experiencing episodes of euphoria. CBD is the non-psychoactive acid that will not get one “high” but will help to counteract the effects of THC, such as paranoia.

4) It’s incredibly versatile

On its own, cannabis leaf juice may not taste the best. Fortunately, it’s incredibly versatile and easy to work with. One might add it to a beet-carrot-apple-ginger juice or pour freshly-juiced cannabis leaves into a morning orange juice.

Additionally, because juicing the cannabis leaves will not get one high, they can consume it on-the-go, which means in the car, at the gym or while picking their kids up from school.

5) There are massive health benefits

Read More: https://www.trueactivist.com/5-benefits-of-juicing-cannabis-you-probably-didnt-know-about/

by: Amanda Froelich Posted on April 10, 2017

CBD FOR CHILDREN: WHAT DO PARENTS NEED TO KNOW?

CBD FOR CHILDREN: WHAT DO PARENTS NEED TO KNOW?

Can I give my child CBD is the continuous question we get from many concerned parents and I continue to say YES! We each have an endocannabinoid system built into our body, this system balances our endocrine system.  Cannabinoids are more than medicine to bring us back to balance, cannabinoids are  FOOD for life.  Good for everyone to bring us back to health and also, to bring on even greater health and balance.  In my search, I found this excellent article for you. 

My Best to You – Darlene 

  

Now that hemp-derived CBD is decriminalized at the federal level, many parents have questions about the safety and effectiveness of CBD for children.

In this article, we’ll cover some of the main questions that parents and healthcare practitioners may have about CBD for kids, including:

How CBD works in the body

Evidence supporting CBD for kids with:

Seizure disorders

Autism spectrum disorders

Anxiety and behavioral outbursts

Using CBD as a supplement

Safety concerns

How to talk to your pediatrician about CBD

This article will look at the most recent research on CBD so that you will have the benefit of the most up-to-date information available.

We also asked a nationally renowned cannabis educator, Dustin Sulak, D.O., to weigh in with his views on using CBD for kids.

Ultimately, you’ll be ready to talk to your child’s healthcare provider about whether CBD is right for your child. Or, you may also decide to hold off for now and wait for more placebo-controlled, double-blind clinical trials.

Either way, you’ll be ready to make an informed decision.

HOW DOES CBD WORK?

CBD seems to correct a lot of different mental and physical imbalances. It does this by working in relationship with the endocannabinoid system (ECS).

The ECS is a network of molecules and signaling pathways in our bodies. It uses neurotransmitters called endocannabinoids that target receptors on cell walls to communicate. 

In short, this system’s job is to create balance, or homeostasis, in the body.While endocannabinoids are produced naturally inside our body, there are plant-derived molecules known as phytocannabinoidsthat can also interact with the ECS.

CBD is one of these phytocannabinoids, and it works by mimicking and augmenting what the endocannabinoids do.

There is a growing collection of data indicating that CBD, in conjunction with the ECS, can cause positive changes in some pediatric illnesses.

Keep reading to learn more about the latest research in this area.

CBD FOR KIDS: WHAT DOES THE RESEARCH SAY?

If the child was ill or has a preexisting challenge that they have to overcome, and they want to maintain a good level of health, could CBD be helpful? I think it could be.

— Dr. Dustin Sulak

The clinical research on using CBD for different medical conditions is in its early stages. But there have already been some studies looking specifically at CBD for pediatric conditions.

When pediatric, youth and adolescent patients with epilepsy or autism spectrum disorder (ASD) take CBD as part of observational studies, they tend to experience improvement in a range of symptoms. According to caregivers’ responses to surveys and questionnaires, these include:

  • Anxiety
  • Depression
  • Sleep disturbances
  • Hyperactivity
  • Hypersensitivity
  • Communication problems

For example, a promising study out of Israel shows holistic improvement in anxiety and behavioral problems in children with autism who participated in the observational study.

But does CBD help get to the root of the problem, or is it better for managing symptoms? Let’s take a look at the research on CBD for specific pediatric health conditions.

CBD FOR CHILDREN WITH AUTISM

The dramatic results of CBD for epilepsy has been encouraging for parents of children with autism spectrum disorder (ASD). That’s because ASD and epilepsy have intersecting areas of disorder, as well as cross symptoms.

The Centers for Disease Control and Prevention (CDC) characterizes ASD as a neurodevelopmental disorder. In 2018, one in 59 children have ASD, and its numbers are on the rise. ASD was once thought to be strictly inherited, but through recent research an environmental contribution is becoming apparent.

As part of an ASD treatment program, providers at the Soroka University Medical Center in Israel collected data from 188 pediatric ASD patients treated with medical cannabis between 2015 and 2017.

Their results, which they reported in January 2019, suggest that high-CBD, low-THC cannabis oildoes cause positive change in ASD patients.

Data from the study indicates a decline in some of the most distressing symptoms of ASD: restlessness, self-injury, rage attacks, agitation, and sleep problems.

Overall, more than 80% of the parents reported a significant or moderate improvement in their child’s global assessment score.

While these are extremely promising improvements, the researchers noted that there were limitations to their study. Specifically, because it was an observational study, there was no control group. Still, this is a first step toward demonstrating the need for more clinical trials.

WHAT DO PARENTS NEED TO KNOW ABOUT USING CBD FOR ASD?

According to pediatrician Bonni Goldstein, MD, there are some risks regarding CBD use in ASD. She says that CBD alone can be overstimulating for some children with behavioral conditions and/or autism, and low doses may worsen hyperactivity.

For these reasons, if you think that your child with ASD would benefit from CBD, dosing efforts and cannabinoid ratios should be monitored by a professional.

CBD FOR CHILDREN WITH ANXIETY AND HEIGHTENED BEHAVIORAL RESPONSES

We feel that CBD is safe based on the all the reports and widespread use, but I wouldn’t start with CBD. I would start with lifestyle changes, exercise, time in nature, amount of sleep, boosting endocannabinoid levels with diet, and avoiding toxins.

— Dr. Dustin Sulak

If your child experiences anxiety or behavioral outbursts, you’ll surely be interested in a plant-derived, safe supplement that quiets neurotoxic excitability states. And if your child deals with higher-than-average levels of anxiety, but they don’t have a diagnosis attached to their symptoms, you may be wondering whether CBD could help.

One study of 93 children with ASD and 93 children without ASD showed differences in their brains. The ASD brains had decreased levels of the endocannabinoid anandamide.

Disrupted levels of our endogenous cannabinoid anandamide are also implicated in anxiety disorders. CBD may have therapeutic potential as an anxiolytic by keeping anandamide around longer.

Also, CBD may inhibit anxiety-provoking hormones at the serotonin target receptor. When CBD inhibits activity at the serotonin receptor, the action is to quell behavioral responses, quiets neurotoxic excitability states and decrease stress reactions in the brain.

The ECS is heavily involved in forming brain cells and reorganizing synaptic pathway connections. This is called neuroplasticity, a process of growth inherent in active learning, yet also necessary for acquiring more balanced emotional responses to the world at large.

SHOULD PARENTS USE CBD AS A SUPPLEMENT FOR THEIR KIDS?Prior to now, a family with a chronically ill child typically decided to use phytocannabinoids for their child after all conventional medical options had failed.

Now it is easy to obtain CBD, and we have more information at hand regarding safety and efficacy. But if you’re thinking of adding CBD to your healthy child’s regimen of supplements, you should be aware that we still don’t know whether it is prudent to jump to external supplementation.

During a webinar hosted by Healer.com, I spoke to Dustin Sulak, D.O., an integrative medicine practitioner and cannabis educator.

Dr. Sulak offered valuable advice for parents who are interested in giving CBD to their healthy child as a general wellness supplement.

“I would start by saying, we don’t know much at all about CBD as a general wellness supplement in children and I would always use more caution in children. I think what we know about CBD makes me feel like it’s very safe. Even at super high doses, [in studies] it is safe. And to use CBD as a tonic at low doses would probably also be safe. But if I were counseling a parent on general wellness approaches I would not be starting with CBD


“We feel that CBD is safe based on the all the reports and widespread use, but I wouldn’t start with CBD,” he said. “I would start with lifestyle changes, exercise, time in nature, amount of sleep, boosting endocannabinoid levels with diet, and avoiding toxins.”


“We live in a toxic environment, chemical toxins, electromagnetic fields, social toxins, and stressors at school. But still, I would do supplements last, and I would probably choose Vitamin D, magnesium, or Omega 3 supplements over CBD.”

Dr. Sulak acknowledges that this is a sensitive subject, and we don’t have information to provide a definitive answer to this question. Ultimately, though, he believes in parental health sovereignty and transparent discussion with your health provider.“If the child was ill or has a preexisting challenge that they have to overcome, and they want to maintain a good level of health, could CBD be helpful? I think it could be. And I would not hesitate to give low doses to someone who needed it. I would supplement CBD at a very low dose of 1 to 5 milligrams,” he said.

“Another option would be to supplement as a tea. Hemp flower tea has CBDA, CBD and THCA and a tiny little bit of THC. This might be a nice approach, as well as a gentler approach.”

READ THE ENTIRE STORY – CLICK HERE

Our Brain on HEMP!

Our Brain on HEMP!

In today’s society, there are many people who still have a negative connotation surrounding hemp. It is a lot of past thoughts associated with a marijuana plant. However, although they are similar, they are different varieties of plants from one another.

Hemp and Marijuana actually have opposite effects on the brain when consumed. The type of hemp that is consumed by humans has been bred to contain very little of the active ingredient in marijuana and more essential nutrients. When marijuana is consumed it has a negative impact on brain development, where hemp consumption is correlated with positive development.

This is largely in part due to hemp containing essential fatty acids, also known as EFAs. The discovery of the health benefits of EFAs is one of the most important nutritional breakthroughs in recent history. Specifically, researchers have noted that omega-3 fatty acids found in hemp are one of the most important nutrients in optimizing brain function and your overall health.

One of the main ways that this occurs is through omega-3s making cell membranes more fluid. This, in turn, helps improve communication between brain cells, which induces brain development. A positive development that comes from fluidity is a boost in memory. The less omega-3s in a person’s brain, the less fluid all your memories are, making it harder to recollect specific things. As you ingest omega-3s, your memories become more fluid and flexible to remember certain times.

The amount of omega-3s are also highly correlated with intelligence and cognitive performance in infants and young children. As the person begins to grow older, omega-3’s are slowly lost from the brain affecting the person’s memory. Scientists suspect that because EFAs are lost as a person grows older and that it could be correlated with cognitive disorders like aggression, depression, anxiety and more serious diseases such as Alzheimer’s and Parkinson’s. This makes it that much more important for a person to make sure they are ingesting the proper amount of omega-3s, in order to keep the brain’s productivity at a high level.

Since hemp provides the perfect ratio of Omega- 6 to Omega-3 then the EFA’s found in hemp seeds are easily digestible. Due to this, our brains can fully benefit from a daily intake of hemp-based products.

-Jack Keegan

https://evohemp.com/pages/the-roots